Research Overview

 The center research targets physiological challenges faced during the exploration of  environmental extremes from ocean depths to space exploration.

Diving related research includes:

  • Research on human diving and altitude physiology including the mechanisms of immersion pulmonary edema, and, respiratory mechanics and gas exchange at non-standard pressures.
  • Evidenced based diagnosis and treatment of decompression sickness and arterial gas embolization.
  • Decompression sickness risk assessment for differing decompression algorithms.
  • Non-clinical (laboratory) diagnosis of decompression illness.

The center faculty also conduct bench research, epidemiological research and clinical trials related to:

  • Human diseases treated with hyperbaric oxygen including: necrotizing infections, osteoradionecrosis of the jaw, soft tissue radionecrosis and bisphosphonate associated osteonecrosis of the jaw.
  • The molecular biology of metabolic gases (O2, CO NO).
  • The clinical and molecular biology of wound healing
  • Treatment of carbon monoxide poisoning.

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NAVSEA CO2 Narcosis Study

Hypercapnia: Cognitive Effects and Monitoring Jake Freiberger, MD, MPH, Bruce J Derrick MD, Tiffany Cobb MSIII, Mike J Natoli MS, Eric A Schinazi, Stephanie E Martina, Michael Qin PhD, Marlon Medford MD, Judith H Viola MD, Nicola Scafetta PhD, Richard E Moon MD NAVSEA Deep Submergence Biomedical Contract #N0463A-12-C-0001 Goals: Reduce operational risk to the …

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Recent NAVSEA CO2 Narcosis Study Photos


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IPE Screening Study

Research Photos

Research Photographs from 2010-2011

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Riociguat 4-21-2014-312

Riociguat Test of Enhancement of Exercise Performance at Altitude

Ventilation /perfusion mismatching during high altitude hypoxia impairs exercise ability. Can riociguat, a pharmacological inhibitor of hypoxic pulmonary vasoconstriction, alleviate this effect? Impairment of exercise performance during altitude exposure is caused primarily by lower arterial oxygen content leading to reduced oxygen delivery to exercising muscles. Ultimately, hypoxemia results in hypoxic pulmonary vasoconstriction (HPV), causing pulmonary …

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Mitochondrial Biogenesis and CO

Doxorubicin disrupts cardiac mitochondrial biogenesis, which promotes intrinsic apoptosis, while CO/HO promotes mitochondrial biogenesis and opposes apoptosis, forestalling fibrosis and cardiomyopathy (A) Representative gross and microscopic pathology. Left column: Cross-sections of mouse hearts fixed at a constant intracavitary pressure illustrate DOX-induced cardiomyopathy after 14 days. Normal mouse heart (control), CO control (CO), and DOX cross-sections …

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Altitude Research

Effect of Altitude Acclimatization on Lung NO and CO Concentration and Vascular Tone in Humans (Drs. Bar-Yosef, Piantadosi, Moon). A joint study with members from the Department of Medicine examining the hypothesis that PO2-related changes in pulmonary and systemic vascular resistance in humans are mediated by changes in pulmonary NO and CO content. Analysis is …

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Immersion Pulmonary Edema

Click on photo for information about the screening for IPE       Immersion Pulmonary Edema Follow Up Study (click photo below)

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Lung Injury and Repair

Drs. Piantadosi, Welty-Wolf, Carraway). Animal models have been developed to study acute lung injury due to oxygen toxicity and sepsis. Methods of assessment include gas exchange (blood gases and multiple inert gas elimination), mechanics, lung morphometry, and measurement of pulmonary inflammatory responses and activation of the coagulation system. In addition, mechanisms or systemic organ injury, …

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