The initial chamber for Hypo-Hyperbaric research was installed at Duke in 1963. During the years between 1963 and 1968, the major investigational activity was directed toward descriptive studies of the effects of hyperbaric oxygen. Oxygen toxicity, problems of oxygen transport through defective macro and micro circulations, physiological effects of hyperoxia upon intact organisms and specific body organs, relevant pathological studies, and biochemical investigations at the cellular level were the major concerns. These pioneering studies resulted primarily in better definition of processes that limited the therapeutic exploitation of hyperbaric oxygen. Many of the basic biochemical and pharmacological mechanisms of action of oxygen, however, remain under investigation.
Construction of the F.G. Hall Laboratory – now part of the Center For Hyperbaric Medicine And Environmental Physiology ( named after Frank Gregory Hall, pictured left) was completed in 1968. Six large chambers were installed which gave capacity to simulate depths of 1000 feet of seawater (fsw) and up to 100,000 feet of altitude. Dr. Herbert Saltzman was named Director of the Laboratory. Under his direction, program investigators emphasized studies of cardiopulmonary, hematologic and neurologic consequences of exposure to substantially high or low atmospheric pressure. The increase and decrease of atmospheric pressures, in association with specialized breathing gases as forcing functions, were used to address such diverse questions as the effects of inert gases on ventilatory control, psychomotor effects of greatly increased atmospheric pressure on man, consequences of immersion and simulated altitude on gas exchange in man and the effects of gas density and atmospheric pressure on ventilatory control and gas exchange. Basic questions have also been investigated concerning the membrane effects of inert gases and anesthetic mechanisms. Extensive applied studies aimed at understanding clearance of gases from body tissues during decompression from depth and to altitude also have been noteworthy.
became a University Center and in 1990 Dr. Claude A. Piantadosi became the Director. In 1998, the facility was designated the Center for Hyperbaric Medicine and Environmental Physiology.